A comparison of machine learning techniques for detection of drug target articles Articles uri icon

publication date

  • December 2010

start page

  • 902

end page

  • 913

issue

  • 6

volume

  • 43

International Standard Serial Number (ISSN)

  • 1532-0464

abstract

  • Important progress in treating diseases has been possible thanks to the identification of drug targets. Drug targets are the molecular structures whose abnormal activity, associated to a disease, can be modified by drugs, improving the health of patients. Pharmaceutical industry needs to give priority to their identification and validation in order to reduce the long and costly drug development times. In the last two decades, our knowledge about drugs, their mechanisms of action and drug targets has rapidly increased. Nevertheless, most of this knowledge is hidden in millions of medical articles and textbooks. Extracting knowledge from this large amount of unstructured information is a laborious job, even for human experts. Drug target articles identification, a crucial first step toward the automatic extraction of information from texts, constitutes the aim of this paper. A comparison of several machine learning techniques has been performed in order to obtain a satisfactory classifier for detecting drug target articles using semantic information from biomedical resources such as the Unified Medical Language System. The best result has been achieved by a Fuzzy Lattice Reasoning classifier, which reaches 98% of ROC area measure.

keywords

  • biomedical text classification; biomedical information retrieval; drug discovery; drug target; machine learning; support vector machines; naïve bayes; unified medical language system; metamap