Influence of Addition of Antibiotics on Chemical and Surface Properties of Sol-Gel Coatings Articles uri icon

authors

  • TOIRAC CHAVEZ, BEATRIZ DUNIA
  • GARCIA CASAS, AMAYA
  • MONCLUS PALAZON, MIGUEL ALBERTO
  • AGUILERA CORREA, JOHN J.
  • ESTEBAN, JAIME
  • JIMENEZ MORALES, ANTONIA

publication date

  • July 2022

start page

  • 1

end page

  • 20

issue

  • 14, 4752

volume

  • 15

International Standard Serial Number (ISSN)

  • 1996-1944

abstract

  • Infection is one of the most common causes that leads to joint prosthesis failure. In the
    present work, biodegradable sol-gel coatings were investigated as a promising controlled release of antibiotics for the local prevention of infection in joint prostheses. Accordingly, a sol-gel formulation was designed to be tested as a carrier for 8 different individually loaded antimicrobials. Sols were prepared from a mixture of MAPTMS and TMOS silanes, tris(tri-methylsilyl)phosphite, and the corresponding antimicrobial. In order to study the cross-linking and surface of the coatings, a battery of examinations (Fourier-transform infrared spectroscopy, solid-state 29Si-NMR spectroscopy, thermogravimetric analysis, SEM, EDS, AFM, and water contact angle, thickness, and roughness measurements) were conducted on the formulations loaded with Cefoxitin and Linezolid. A formulation loaded with both antibiotics was also explored. Results showed that the coatings had a microscale roughness attributed to the accumulation of antibiotics and organophosphites in the surface protrusions and that the existence of chemical bonds between antibiotics and the siloxane network was not evidenced.

subjects

  • Chemistry
  • Materials science and engineering

keywords

  • antibiotics-loaded sol-gel coatings; afm; sem; solid-state 29si-nmr spectroscopy; fourier-transform infrared spectroscopy