Improving PET Quantification of Small Animal [Ga-68]DOTA-Labeled PET/CT Studies by Using a CT-Based Positron Range Correction Articles uri icon

publication date

  • August 2018

start page

  • 584

end page

  • 593

issue

  • 4

volume

  • 20

International Standard Serial Number (ISSN)

  • 1536-1632

Electronic International Standard Serial Number (EISSN)

  • 1860-2002

abstract

  • Image quality of positron emission tomography (PET) tracers that emits high-energy positrons, such as Ga-68, Rb-82, or I-124, is significantly affected by positron range (PR) effects. PR effects are especially important in small animal PET studies, since they can limit spatial resolution and quantitative accuracy of the images. Since generators accessibility has made Ga-68 tracers wide available, the aim of this study is to show how the quantitative results of [Ga-68]DOTA-labeled PET/X-ray computed tomography (CT) imaging of neuroendocrine tumors in mice can be improved using positron range correction (PRC).

keywords

  • emission-tomography; preclinical evaluation; mathematical removal; spatial-resolution; magnetic-field; shine-through; image-quality; 3d pet; reconstruction; system