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This work focuses on the bioactivity and biological response of modified Ti surfaces produced by powder metallurgy. They are processed by diffusion of two beta-stabilizing elements, Nb and Mo, deposited onto the surface of PM Ti substrates. Moreover, the addition of an activating agent, NH4Cl, to the suspension has been carried out by thermo-reactive diffusion process. The surface modification led to a gradient in composition (Ti-Nb or Ti-Mo) and microstructure (beta / alpha + beta / alpha phases). This work presents the bioactivity results of these Ti-Mo and Ti-Nb surfaces as well as the cell-material response of the Ti-Nb surfaces. The reactivity of the materials was tested through immersion in simulated body fluid considering Ca and P precipitation in order to assess the ability of the materials to induce hydroxyapatite formation. The in-vitro cell response was evaluated by human osteoblast-like cells incubation on the different surfaces for 48 h. The investigation led to positive results in terms of surface bioactivity and an improved cell-material interaction of the PM modified Ti-Nb surfaces compared to the reference Ti material.