Response to Deep Brain Stimulation in Three Brain Targets with Implications in Mental Disorders: A PET Study in Rats Articles uri icon

publication date

  • December 2016

issue

  • 12

volume

  • 11

international standard serial number (ISSN)

  • 1932-6203

abstract

  • Objective To investigate metabolic changes in brain networks by deep brain stimulation (DBS) of the medial prefrontal cortex (mPFC), nucleus accumbens (NAcc) and dorsomedial thalamus (DM) using positron emission tomography (PET) in naive rats. Methods 43 male Wistar rats underwent stereotactic surgery and concentric bipolar platinum-iridium electrodes were bilaterally implanted into one of the three brain sites. [F-18]-fluoro-2-deoxyglucose-PET ((18)FDG-PET) and computed tomography (CT) scans were performed at the 7th (without DBS) and 9th day (with DBS) after surgery. Stimulation period matched tracer uptake period. Images were acquired with a small-animal PET-CT scanner. Differences in glucose uptake between groups were assessed with Statistical Parametric Mapping.

keywords

  • treatment-resistant depression; cerebral-blood-flow; nucleus-accumbens; animal-models; psychiatric-disorders; parkinsons-disease; glucose-metabolism; prefrontal cortex; clinical-practice; frontal-cortex