Stochastic model of tumor-induced angiogenesis: ensemble averages and deterministic equations Articles uri icon

publication date

  • February 2016

issue

  • 2

volume

  • 93

international standard serial number (ISSN)

  • 2470-0045

electronic international standard serial number (EISSN)

  • 2470-0053

abstract

  • A recent conceptual model of tumor-driven angiogenesis including branching, elongation, and anastomosis of blood vessels captures some of the intrinsic multiscale structures of this complex system, yet allowing one to extract a deterministic integro-partial-differential description of the vessel tip density [Phys. Rev. E 90, 062716 (2014)]. Here we solve the stochastic model, show that ensemble averages over many realizations correspond to the deterministic equations, and fit the anastomosis rate coefficient so that the total number of vessel tips evolves similarly in the deterministic and ensemble-averaged stochastic descriptions.

keywords

  • sprouting angiogenesis
    endothelial cells
    growth factor
    mechanisms
    simulations
    disease