Comparison of Methods to Reduce Myocardial 18F-FDG Uptake in Mice: Calcium Channel Blockers versus High-Fat Diets Articles uri icon

publication date

  • September 2014

start page

  • 1

end page

  • 6

issue

  • 9

volume

  • 9

international standard serial number (ISSN)

  • 1932-6203

abstract

  • Besides its application in oncology, 18F-FDG PET-CT imaging is also useful in the diagnosis of certain lung infections, inflammatory diseases, and atherosclerotic plaques. Myocardial uptake of 18F-FDG may hamper visualization of the lesions caused by these diseases. Two approaches have been proposed for reducing myocardial uptake in preclinical studies, namely, calcium channel blockers (verapamil) and high-fat diets such as commercial ketogenic diets and sunflower seed diets. The objective of this study was to compare the efficacy of these approaches in reducing myocardial uptake of 18F-FDG in mice.

keywords

  • oncology; 18f-fdg pet-ct; lung infections; inflammatory diseases; atherosclerotic plaques; myocardial uptake; calcium channel blockers; verapamil; high-fat diet; ketogenic diet; sunflower seed diet