A novel approach to investigate neuronal network activity patterns affected by deep brain stimulation in rats Articles uri icon

publication date

  • July 2011

start page

  • 927

end page

  • 930

issue

  • 7

volume

  • 45

international standard serial number (ISSN)

  • 0022-3956

electronic international standard serial number (EISSN)

  • 1879-1379

abstract

  • The establishment of new therapeutic indications for deep brain stimulation (DBS) is ambitiously promoted though the underlying mechanisms remain contested. Here, we report that PET-imaging and subsequent c-Fos-immunostaining in rats constitute a new translational approach to further understand DBS-mechanisms and -effectiveness.

keywords

  • deep brain stimulation; subthalamic nucleus; fdg-pet; c-fos-immunostaining; brain activity patterns