Current Understanding of the Neural Stem Cell Niches Articles uri icon

published in

publication date

  • October 2022

issue

  • 19

volume

  • 11

International Standard Serial Number (ISSN)

  • 2073-4409

abstract

  • (copyright) 2022 by the authors.Neural stem cells (NSCs) are self-renewing, multipotent cells which give rise to all components of the central nervous system (CNS) during embryogenesis, but also activate in response to injury and disease and maintain a certain level of neurogenic activity throughout adulthood. This activity takes place in specialized regions of the brain, the neurovascular niches, whose main role is to control the behaviour of the CNS. In adult mammals, two main 'canonical' niches have been described: The subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) of the dentate gyrus. This review discusses our current understanding of the neural stem cells and their canonical niches, as well as their structure, behaviours, and role in neural disease.

keywords

  • brain; neurogenesis; niche; stem cell; subgranular zone; subventricular zone; vasculature