Performance of ultra-high-frequency ultrasound in the evaluation of skin involvement in systemic sclerosis: a preliminary report Articles uri icon

publication date

  • October 2019

start page

  • 1671

end page

  • 1678


  • 7


  • 59

International Standard Serial Number (ISSN)

  • 1462-0324


  • High frequency ultrasound allows visualization of epidermis, dermis and hypodermis, precise measurement of skin thickness, as well as assessment of skin oedema, fibrosis and atrophy. The aim of this pilot cross-sectional observational study was to assess the performance and multiobserver variability of ultra-high-frequency (UHF) (50 MHz) ultrasound (US) in measuring skin thickness as well as the capacity of UHF-derived skin features to differentiate SSc patients from healthy controls.


  • systemic sclerosis; high frequency ultrasound; sonography; dermis; hypodermis; scleroderma; skin; skin ultrasound; skin involvement; modified rodnan skin score