Closed-loop deep brain stimulation based on a stream-clustering system Articles uri icon

publication date

  • July 2019

start page

  • 187

end page

  • 199


  • 126

International Standard Serial Number (ISSN)

  • 0957-4174

Electronic International Standard Serial Number (EISSN)

  • 1873-6793


  • Idiopathic Parkinsons disease (PD) is currently the second most important neurodegenerative disease in incidence. Deep brain stimulation (DBS) constitutes a successful and necessary therapy; however, the continuous stimulation it provides can be associated with multiple side effects. DBS uses an implanted pulse generator that delivers, through a set of electrodes, electrical stimulation to the target area, normally the Sub Thalamic Nucleus. Recently, Closed-loop DBS has emerged as a promising new strategy, where the device stimulates only when necessary, thereby reducing any adverse effects. Here, we present a Closed-loop DBS system for PD, which is able to recognize, with 100% accuracy, when the patient is going to enter into the tremor phase, thus allowing the device to stimulate only in such cases. The expert system has been designed and implemented within the data stream mining paradigm, suitable for our scenario since it can cope with continuous data of a theoretical infinite length and with a certain variability, which uses the synchronization among the neural population within the Sub Thalamic Nucleus as the continuous data stream input to the system. (C) 2019 Elsevier Ltd. All rights reserved.


  • clustering; data stream mining (dsm); expert system; deep brain stimulation(dbs); parkinson's disease (pd); neural engineering; high-frequency stimulation; subthalamic nucleus; oscillatory activity; parkinsonian tremor; disease; connectivity; improvement; rhythm