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In recent years, institutions of higher education have been using Massive Open Online Courses (MOOCs) as an alternative to enhance and innovate traditional classroom practices. One of the approaches to this type of innovation consists of using the platforms where MOOCs are hosted for the development of courses that are aligned to their on-campus curricular contents. They are known as Small Private Online Courses (SPOCs), which allow online access to knowledge for groups of students with a well-defined profile. The platforms where MOOCs (and SPOCs) are hosted have been designed to support large volumes of data and visits. However, these platforms present important limitations regarding the implementation of collaborative learning activities. To address this problem, this article presents MyMOOCSpace, a cloud-based mobile system aimed at supporting effective collaboration in MOOCs, by combining key aspects of collaboration from the research area of Computer Supported Collaborative Learning (CSCL) with game-based dynamics. MyMOOCSpace has been tested in three quasi-experiments that were run in four Latin-American universities with a total of 68 participants. The objective was to assess its usability and its effect in enhancing collaboration among students in a SPOC. The results obtained on usability show that MyMOOCSpace is easy to use, and that participants felt pleased with while using it. Finally, it was observed that MyMOOCSpace managed to enhance interaction and collaboration among students.