Predicting symptom severity in autism spectrum disorder based on cortical thickness measures in agglomerative data

Machine learning approaches have been widely used for the identification of neuropathology from neuroimaging data. However, these approaches require large samples and suffer from the challenges associated with multi-site, multi-protocol data. We propose a novel approach to address these challenges, and demonstrate its usefulness with the Autism Brain Imaging Data Exchange (ABIDE) database. We predict symptom severity based on cortical thickness measurements from 156 individuals with autism spectrum disorder (ASD) from four different sites. The proposed approach consists of two main stages: a domain adaptation stage using partial least squares regression to maximize the consistency of imaging data across sites; and a learning stage combining support vector regression for regional prediction of severity with elastic-net penalized linear regression for integrating regional predictions into a whole-brain severity prediction.

diagnostic observation schedule; superior temporal sulcus; social cognition; joint attention; typical development; ados scores; brain mri; children; perception; regression; autism spectrum disorder; magnetic resonance imaging; cortical thickness; machine learning; domain adaptation

Predicting symptom severity in autism spectrum disorder based on cortical thickness measures in agglomerative data Articles