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As large-scale distributed systems gain momentum, the scheduling of workflow applications with multiple requirements in such computing platforms has become a crucial area of research. In this paper, we investigate the workflow scheduling problem in large-scale distributed systems, from the Quality of Service (QoS) and data locality perspectives. We present a scheduling approach, considering two models of synchronization for the tasks in a workflow application: (a) communication through the network and (b) communication through temporary files. Specifically, we investigate via simulation the performance of a heterogeneous distributed system, where multiple soft real-time workflow applications arrive dynamically. The applications are scheduled under various tardiness bounds, taking into account the communication cost in the first case study and the I/O cost and data locality in the second.