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Brain volume and thickness abnormalities have been reported in first-episode psychosis (FEP). However, it is unclear if and how they are modulated by brain developmental stage (and, therefore, by age at FEP as a proxy). This is a multicenter cross-sectional case-control brain magnetic resonance imaging (MRI) study. Patients with FEP (n = 196), 65.3% males, with a wide age at FEP span (12-35 y), and healthy controls (HC) (n = 157), matched for age, sex, and handedness, were scanned at 6 sites. Gray matter volume and thickness measurements were generated for several brain regions using FreeSurfer software. The nonlinear relationship between age at scan (a proxy for age at FEP in patients) and volume and thickness measurements was explored in patients with schizophrenia spectrum disorders (SSD), affective psychoses (AFP), and HC.
childhood-onset schizophrenia; human cerebral-cortex; gray-matter volume; phenotypes b-snip; bipolar disorder; 1st-episode schizophrenia; neurodevelopmental trajectories; cortical development; hippocampal volume; early adulthood; first-episode psychosis; age at onset; schizophrenia; bipolar disorder; cortical thickness; cortical volume; mri