The human cerebral cortex flattens during adolescence Articles uri icon

authors

  • ALEMAN GOMEZ, YASSER
  • JANSSEN, JOOST
  • SCHNACK, HUGO
  • BALABAN, EVAN
  • PINA-CAMACHO, LAURA
  • ALFARO ALMAGRO, FIDEL
  • CASTRO FORNIELES, JOSEFINA
  • OTERO, SORAYA
  • BAEZA, IMMACULADA
  • MORENO, DOLORES
  • BARGALLO, NURIA
  • PARELLADA, MARIA DOLORES
  • ARANGO, CELSO
  • DESCO MENENDEZ, MANUEL

publication date

  • September 2013

start page

  • 15004

end page

  • 15010

issue

  • 38

volume

  • 33

international standard serial number (ISSN)

  • 0270-6474

electronic international standard serial number (EISSN)

  • 1529-2401

abstract

  • The human cerebral cortex appears to shrink during adolescence. To delineate the dynamic morphological changes involved in this process, 52 healthy male and female adolescents (11-17 years old) were neuroimaged twice using magnetic resonance imaging, approximately 2 years apart. Using a novel morphometric analysis procedure combining the FreeSurfer and BrainVisa image software suites, we quantified global and lobar change in cortical thickness, outer surface area, the gyrification index, the average Euclidean distance between opposing sides of the white matter surface (gyral white matter thickness), the convex ("exposed") part of the outer cortical surface (hull surface area), sulcal length, depth, and width. We found that the cortical surface flattens during adolescence. Flattening was strongest in the frontal and occipital cortices, in which significant sulcal widening and decreased sulcal depth co-occurred. Globally, sulcal widening was associated with cortical thinning and, for the frontal cortex, with loss of surface area. For the other cortical lobes, thinning was related to gyral white matter expansion. The overall flattening of the macrostructural three-dimensional architecture of the human cortex during adolescence thus involves changes in gray matter and effects of the maturation of white matter.