Feasibility study of endoscopic x-ray luminescence computed tomography: Simulation demonstration and phantom application Articles uri icon

publication date

  • August 2013

start page

  • 1

end page

  • 5

issue

  • 8(e084701)

volume

  • 114

international standard serial number (ISSN)

  • 0021-8979

electronic international standard serial number (EISSN)

  • 1520-8850

abstract

  • Even though endoscopic fluorescence diffuse optical tomography (eFDOT) exhibits significant potential, currently its application is limited due to the existence of strong autofluorescence and the imaging inaccuracy caused by a very short source-detector distance. Motivated by the emerging X-ray luminescence computed tomography (XLCT) technology, we presented an endoscopic XLCT (eXLCT) methodology. In the methodology, the aperture angle of the objective was incorporated into the forward model, providing a more accurate description of light propagation. Numerical simulation with a heterogeneous geometry and an imaging experiment with a physical phantom were illustrated to demonstrate the feasibility of the presented eXLCT methodology. (C) 2013 AIP Publishing LLC.

keywords

  • optical tomography; light propagation; near infrared spectroscopy ; nanoparticles ; boundary value problems