The Application of Nanoparticles in Gene Therapy and Magnetic Resonance Imaging Articles uri icon

authors

  • HERRANZ, FERNANDO
  • ALMARZA, ELENA
  • RODRIGUEZ FERNANDEZ, IGNACIO
  • SALINAS, BEATRIZ
  • ROSELL, YAMILKA
  • DESCO MENENDEZ, MANUEL
  • BULTE, JEFF W.
  • RUIZ-CABELLO, JESUS

publication date

  • July 2011

start page

  • 577

end page

  • 591

issue

  • 7

volume

  • 74

international standard serial number (ISSN)

  • 1059-910X

electronic international standard serial number (EISSN)

  • 1097-0029

abstract

  • The combination of nanoparticles, gene therapy, and medical imaging has given rise to a new field known as gene theranostics, in which a nanobioconjugate is used to diagnose and treat the disease. The process generally involves binding between a vector carrying the genetic information and a nanoparticle, which provides the signal for imaging. The synthesis of this probe generates a synergic effect, enhancing the efficiency of gene transduction and imaging contrast. We discuss the latest approaches in the synthesis of nanoparticles for magnetic resonance imaging, gene therapy strategies, and their conjugation and in vivo application.

keywords

  • nanoparticles; bioimaging; gene therapy; iron oxide; theranostic