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This work presents analytical and finite element analysis (FEA) results of the thermo-mechanical non-linear response of an axi-symmetric circular sandwich plates with a compliant foam core. The study investigates the load&-thermal interaction response of a sandwich panel where the properties of the core are temperature dependent and degrade as the temperatures are raised. It presents briefly the governing equations for a sandwich plate based on the principles of the high-order sandwich panel theory (HSAPT) which incorporates the effects of the vertical flexibility of the core material as well as the effects of temperature independent/dependent mechanical properties of the foam core. The effects of the thermal degradation of core material on the thermo-mechanical non-linear response of a simply supported circular sandwich plate are studied through the analytical and FE models. The difficulties involved in non-linear geometrical FE modeling of sandwich panels with a compliant "soft" core with temperature-dependent mechanical properties are discussed. The HSAPT model predictions are compared very well with FE result. An important conclusion of the study is that the interaction between mechanical loads, temperature induced deformations, and degradation of the mechanical properties due to elevated temperatures, may seriously affect the structural integrity of foam cored sandwich plates.