ImmunoPET Directed to the Brain: A New Tool for Preclinical and Clinical Neuroscience Articles uri icon

publication date

  • January 2023

start page

  • 1

end page

  • 16

issue

  • 1

volume

  • 13

International Standard Serial Number (ISSN)

  • 2218-273X

abstract

  • Immuno-positron emission tomography (immunoPET) is a non-invasive in vivo imaging method based on tracking and quantifying radiolabeled monoclonal antibodies (mAbs) and other related molecules, such as antibody fragments, nanobodies, or affibodies. However, the success of immunoPET in neuroimaging is limited because intact antibodies cannot penetrate the blood-brain barrier (BBB). In neuro-oncology, immunoPET has been successfully applied to brain tumors because of the compromised BBB. Different strategies, such as changes in antibody properties, use of physiological mechanisms in the BBB, or induced changes to BBB permeability, have been developed to deliver antibodies to the brain. These approaches have recently started to be applied in preclinical central nervous system PET studies. Therefore, immunoPET could be a new approach for developing more specific PET probes directed to different brain targets.

subjects

  • Biology and Biomedicine
  • Medicine

keywords

  • positron emission tomography; neuroimaging; immunopet; brain; blood-brain barrier; antibody engineering; neuroscience; neuro-oncology; neurology; neuropsychiatry