Targeting MT1-MMP as an ImmunoPET-Based Strategy for Imaging Gliomas Articles uri icon

authors

  • GARCIA DE LUCAS, ANGEL
  • Jiménez Schuhmacher, Alberto
  • Oteo Vives, Marta
  • Romero Sanz, Eduardo
  • Cámara Serrano, Juan Antonio
  • De Martino Rodriguez, Alba
  • García Arroyo, Alicia
  • Morcillo Alonso, Miguel Ángel
  • Squatrito, Massimo
  • Martínez Torrecuadrada, Jorge Luis
  • Mulero, Francisca

publication date

  • July 2016

start page

  • 1

end page

  • 19

issue

  • 7

volume

  • 11

International Standard Serial Number (ISSN)

  • 1932-6203

abstract

  • A critical challenge in the management of Glioblastoma Multiforme (GBM) tumors is the accurate diagnosis and assessment of tumor progression in a noninvasive manner. We have identified Membrane-type 1 matrix metalloproteinase (MT1-MMP) as an attractive biomarker for GBM imaging since this protein is actively involved in tumor growth and progression, correlates with tumor grade and is closely associated with poor prognosis in GBM patients. Here, we report the development of an immunoPET tracer for effective detection of MT1-MMP in GBM models.

subjects

  • Biology and Biomedicine
  • Medicine