Classics in Chemical Neuroscience: Haloperidol Articles uri icon

publication date

  • March 2017

start page

  • 444

end page

  • 453

issue

  • 3

volume

  • 8

International Standard Serial Number (ISSN)

  • 1948-7193

abstract

  • The discovery of haloperidol catalyzed a breakthrough in our understanding of the biochemical basis of schizophrenia, improved the treatment of psychosis, and facilitated deinstitutionalization. In doing so, it solidified the role for chemical neuroscience as a means to elucidate the molecular underpinnings of complex neuropsychiatric disorders. In this Review, we will cover aspects of haloperidol"s synthesis, manufacturing, metabolism, pharmacology, approved and off-label indications, and adverse effects. We will also convey the fascinating history of this classic molecule and the influence that it has had on the evolution of neuropsychopharmacology and neuroscience.

subjects

  • Biology and Biomedicine
  • Pharmacy
  • Psychology

keywords

  • haloperidol; antipsychotic; schizophrenia; dopamine; pharmacology; history