Left ventricular fibrosis and CMR tissue characterization of papillary muscles in mitral valve prolapse patients Articles uri icon

authors

  • SPAMPINATO, RICARDO A.
  • MARIN-CUARTAS, MATEO
  • VAN KAMPEN, ANTONIA
  • FAHR, FLORIAN
  • SIEG, FRANZ
  • STROTDREES, ELFRIEDE
  • JAHNKE, COSIMA
  • KLAESKE, KRISTIN
  • WIESNER, KAROLINE
  • MORNINGSTAR, JORDAN E.
  • NAGATA, YASUFUMI
  • IZQUIERDO GARCÍA, DAVID
  • DIETERLEN, MAJA-THERESA
  • NORRIS, RUSSELL A.
  • LEVINE, ROBERT A.
  • PAETSCH, INGO
  • BORGER, MICHAEL A.

publication date

  • February 2024

start page

  • 213

end page

  • 224

issue

  • 2

volume

  • 40

International Standard Serial Number (ISSN)

  • 1569-5794

Electronic International Standard Serial Number (EISSN)

  • 1875-8312

abstract

  • Purpose: Mitral valve prolapse (MVP) is associated with left ventricle (LV) fibrosis, including the papillary muscles (PM), which is in turn linked to malignant arrhythmias. This study aims to evaluate comprehensive tissue characterization of the PM by cardiovascular magnetic resonance (CMR) imaging and its association with LV fibrosis observed by intraoperative biopsies.

    Methods: MVP patients with indication for surgery due to severe mitral regurgitation (n = 19) underwent a preoperative CMR with characterization of the PM: dark-appearance on cine, T1 mapping, conventional bright blood (BB) and dark blood (DB) late gadolinium enhancement (LGE). CMR T1 mapping was performed on 21 healthy volunteers as controls. LV inferobasal myocardial biopsies were obtained in MVP patients and compared to CMR findings.

    Results: MVP patients (54 ± 10 years old, 14 male) had a dark-appearance of the PM with higher native T1 and extracellular volume (ECV) values compared with healthy volunteers (1096 ± 78ms vs. 994 ± 54ms and 33.9 ± 5.6% vs. 25.9 ± 3.1%, respectively, p 

subjects

  • Biology and Biomedicine

keywords

  • mitral valve prolapse; myocardial fibrosis; cardiovascular magnetic resonance; dark-blood lge; t1-mapping; papillary muscle