Interfacial Self-Assembly to Spatially Organize Graphene Oxide Into Hierarchical and Bioactive Structures Articles uri icon

authors

  • Majkowska, A.
  • Redondo-Gómez, C.
  • Rice, A.
  • GONZALEZ, MARIEL
  • Inostroza-Brito, K.E.
  • Collin, E.C.
  • Rodriguez-Cabello, J.C.
  • RIO HERNANDEZ, ARMANDO EMETERIO DEL
  • Solito, E.
  • Mata, A.

publication date

  • January 2020

start page

  • 1

end page

  • 13

issue

  • 167

volume

  • 7

International Standard Serial Number (ISSN)

  • 2296-8016

abstract

  • Multicomponent self-assembly holds great promise for the generation of complex and functional biomaterials with hierarchical microstructure. Here, we describe the use of supramolecular co-assembly between an elastin-like recombinamer (ELR5) and a peptide amphiphile (PA) to organize graphene oxide (GO) flakes into bioactive structures across multiple scales. The process takes advantage of a reaction—diffusion mechanism to enable the incorporation and spatial organization of GO within multiple ELR5/PA layers. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), and ImageJ software were used to demonstrate the hierarchical organization of GO flakes within the ELR5/PA layers and the distribution profiles of GO throughout the ELR5/PA membranes. Furthermore, atomic force microscopy (AFM) revealed improved Young's Moduli of the ELR5/PA/GO membranes compared to the ELR5/PA membranes. Lastly, we investigated biocompatibility of the ELR5/PA/GO membrane via various cell culture methods.

subjects

  • Biology and Biomedicine

keywords

  • graphene oxide; multicomponent self-assembly; peptide amphiphiles; elastin-like recombinamer; hierarchical biomaterials; composite materials