Targeting the Complexity of In Vitro Skin Models: A Review of Cutting-Edge Developments Articles uri icon

authors

  • QUILEZ LOPEZ, CRISTINA
  • BEBIANO, LUIS B.
  • JONES, ELERI
  • MAVER, UROS
  • MEESTERS, LUCA
  • PARZYMIES, PIOTR
  • PETIOT, EMMA
  • RIKKEN, GIJS
  • RISUEÑO ROJO, IGNACIO
  • ZAIDI, HAMZA
  • ZIDARIC, TANJA
  • BEKESCHUS, SANDER
  • VAN DEN BOGAARD, ELLEN H.
  • CALEY, MATTHEW
  • COLLEY, HELEN
  • GAGO LOPEZ, NURIA
  • LETSIOU, SOPHIA
  • MARQUETTE, CHRISTOPHE
  • MAVER, TINA
  • PEREIRA, RUBEN F.
  • TOBIN, DESMOND J.
  • VELASCO BAYON, DIEGO

publication date

  • December 2024

start page

  • 2650

end page

  • 2670

issue

  • 12

volume

  • 144

International Standard Serial Number (ISSN)

  • 0022-202X

Electronic International Standard Serial Number (EISSN)

  • 1523-1747

abstract

  • Skin in vitro models offer much promise for research, testing drugs, cosmetics, and medical devices, reducing animal testing and extensive clinical trials. There are several in vitro approaches to mimicking human skin behavior, ranging from simple cell monolayer to complex organotypic and bioengineered 3-dimensional models. Some have been approved for preclinical studies in cosmetics, pharmaceuticals, and chemicals. However, development of physiologically reliable in vitro human skin models remains in its infancy. This review reports on advances in in vitro complex skin models to study skin homeostasis, aging, and skin disease.

subjects

  • Biology and Biomedicine

keywords

  • in vitro disease models; in vitro skin aging; in vitro skin models; skin bioprinting; skin on chip