Unravelling the cellular response to the SARS-COV-2 vaccine in inflammatory bowel disease patients on biologic drugs Articles uri icon

authors

  • MARTINEZ DOMINGUEZ, SAMUEL J.
  • GARCIA MATEO, SANDRA
  • SAINZ ARNAL, PILAR
  • MARTINEZ GARCIA, JAVIER
  • GALLEGO LLERA, BEATRIZ
  • LOZANO LIMONES, MARIA JESUS
  • HIDALGO, SANDRA
  • GARGALLO PUYUELO, CARLA J.
  • LATRE SANTOS, MARTA
  • NOCITO COLON, MARIA MERCEDES LOURDES
  • MARTINEZ LOSTAO, LUIS
  • REFAIE, ENGY
  • ARROYO VILLARINO, MARIA TERESA
  • RIO NECHAEVSKY, MARCELA ANDREA DEL
  • RAMIREZ LEBRADA, ARIEL
  • PARDO, JULIAN
  • GOMOLLON, FERNANDO
  • ALMEIDA DE MATOS BAPTISTA, PEDRO MIGUEL

publication date

  • December 2023

start page

  • 1

end page

  • 11

issue

  • 23061

volume

  • 13

International Standard Serial Number (ISSN)

  • 2045-2322

abstract

  • Suboptimal vaccine response is a significant concern in patients with Inflammatory Bowel Disease (IBD) receiving biologic drugs. This single-center observational study involved 754 patients with IBD. In Phase I (October 2020-April 2021), 754 IBD participants who had not previously received the SARS-CoV-2 vaccine, underwent blood extraction to assess the seroprevalence of SARS-CoV-2 infection and IBD-related factors. Phase II (May 2021-October 2021) included a subgroup of 52 IBD participants with confirmed previous SARS-CoV-2 infection, who were studied for humoral and cellular response to the SARS-CoV-2 vaccine. In Phase I, treatment with anti-TNF was associated with lower rates of seroconversion (aOR 0.25 95% CI [0.10-0.61]). In Phase II, a significant increase in post-vaccination IgG levels was observed regardless of biologic treatment. However, patients treated with anti-TNF exhibited significantly lower IgG levels compared to those without IBD therapy (5.32 ± 2.47 vs. 7.99 ± 2.59 U/ml, p = 0.042). Following vaccination, a lymphocyte, monocyte, and NK cell activation pattern was observed, with no significant differences between patients receiving biologic drugs and those without IBD treatment. Despite lower seroprevalence and humoral response to the SARS-CoV-2 vaccine in patients treated with anti-TNF, the cellular response to the vaccine did not differ significantly from that patients without IBD therapy.

subjects

  • Biology and Biomedicine