PARP-1 Targeted Radiotherapy in Mouse Models of Glioblastoma Articles uri icon

authors

  • JANNETTI, STEPHEN A-
  • CARLUCCI, GIUSEPPE
  • CARNEY, BRANDON
  • KOSSATZ, SUZANNE
  • SHENKER, LARISSA
  • SALINAS RODRIGUEZ, BEATRIZ
  • CARTER, LUKAS M.
  • BRAND, CHRISTIAN
  • SADIQUE, AHMAD
  • DONABEDIAN, PATRICK L.
  • CUNANAN, KRISTEN M.
  • GONEN, MITHAT
  • PONOMAREV, VLADIMIR
  • ZEGLIS, BRIAN M.
  • SOUWEIDANE, MARK M.
  • LEWIS, JASON S.
  • WEBER, WOLFGANG A.
  • HUMM, JOHN L.
  • REINER, THOMAS

publication date

  • March 2018

start page

  • 1225

end page

  • 1233

volume

  • 59

International Standard Serial Number (ISSN)

  • 0161-5505

Electronic International Standard Serial Number (EISSN)

  • 1535-5667

abstract

  • The DNA repair enzyme poly(ADP-ribose) polymerase 1 (PARP-1) is overexpressed in glioblastoma, with overall low expression in healthy brain tissue. Paired with the availability of specific small molecule inhibitors, PARP-1 is a near-ideal target to develop novel radiotherapeutics to induce DNA damage and apoptosis in cancer cells, while sparing healthy brain tissue.

subjects

  • Biology and Biomedicine

keywords

  • parp; radiotherapeutic; 131i-parpi; 131i; convection enhanced delivery