Characterisation of Diclofenac, Ketoprofen or Chloramphenicol Succinate encapsulated in layered double hydroxides with the hydrotalcite-type structure Articles uri icon

publication date

  • December 2011

start page

  • 158

end page

  • 163

volume

  • 55

International Standard Serial Number (ISSN)

  • 0169-1317

Electronic International Standard Serial Number (EISSN)

  • 1872-9053

abstract

  • Three series of hybrid organic-inorganic layered double hydroxide samples containing Zn2 + and/or Mg2 + and Al3 + in the brucite-like layers (nominal M2 +/Al molar ratio 2:1) and Diclofenac, Ketoprofen or Chloramphenicol Succinate as counter-anions, were synthesized by coprecipitation using drug/Al molar ratios of 2:1 to prepare the starting solutions. All samples have been characterised by element chemical analysis, powder X-ray diffraction, FT-IR spectroscopy, thermal analysis and morphology analysis (Scanning Electron Microscopy). The nanohybrids here prepared show a rather high crystallinity degree and the drug molecules are strongly interacting with the brucite-like layers.

subjects

  • Biology and Biomedicine

keywords

  • hydrotalcite; drug intercalation; diclofenac; ketoprofen; chloramphenicol; layered double hydroxides