Growth of non-enzymatic cholesterol biosensor using TiO2 decorated graphene oxide with bare GCE and PPy-GCE Articles uri icon

authors

  • Deivanayaki, S.
  • Jayamurugan, P.
  • Ashokan, S.
  • Gopala Krishnan, V.
  • Yogeswari, B.
  • Ubaidullah, Mohd
  • PANDIT, BIDHAN
  • Sarma, G. V.S.S.
  • Narsetti, Hemanth Kumar

publication date

  • March 2023

issue

  • 3, nº artículo 100906

volume

  • 100

International Standard Serial Number (ISSN)

  • 0019-4522

abstract

  • In this work, we report an electrochemical cholesterol biosensor based on cholesterol oxidase(ChOx) enzyme immobilized on TiO2- nanoparticles – reduced graphene oxide(rGO) – polypyrrole (PPy) nanocomposite modified electrode.The electrochemical properties of GCE modified PPy (PPy-GCE) were studied using CV (Cyclic Voltammetry) and DPV (Differential Pulse Voltammetry). The developed sensor exhibited piecewise linearity from 0.1 μM to 1 μM and from 1 μM to 600 μM with the sensitivity of 61.665 and 0.1466 (2 mA mM × cm) respectively. The limit of detection of the sensor was found to be 32 nm.

subjects

  • Chemistry
  • Materials science and engineering

keywords

  • chemical oxidative polymerization; clinical analysis; nanomaterials; non-enzymatic