Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria Articles uri icon

authors

  • O'NEILL, PAUL M.
  • STOCKS, PAUL A.
  • SABBANI, SUNIL
  • ROBERTS, NATALIE L.
  • AMEWU, RICHARD K.
  • SHORE, EMMA R.
  • ALJAYYOUSSI, GHAITH
  • ANGULO BARTUREN, ÍÑIGO
  • BELEN, MARIA
  • JIMENEZ-DIAZ, JD
  • FERRER BAZAGA, SANTIAGO
  • SANTOS MARTINEZ, MARIA
  • CAMPO, BRICE
  • SHARMA, RAMAN
  • CHARMAN, SUSAN A.
  • RYAN, EILEEN
  • CHEN, GONG
  • SHACKLEFORD, DAVID M.
  • DAVIES, JILL
  • NIXON, GEMMA L.
  • BIAGINI, GIANCARLO A.
  • WARD, STEPHEN A.

publication date

  • July 2018

start page

  • 2996

end page

  • 3005

issue

  • 11

volume

  • 26

International Standard Serial Number (ISSN)

  • 0968-0896

Electronic International Standard Serial Number (EISSN)

  • 1464-3391

abstract

  • A series of aryl carboxamide and benzylamino dispiro 1,2,4,5-tetraoxane analogues have been designed and synthesized in a short synthetic sequence from readily available starting materials. From this series of endoperoxides, molecules with in vitro IC50s versus Plasmodium falciparum (3D7) as low as 0.84 nM were identified. Based on an assessment of blood stability and in vitro microsomal stability, N205 (10a) was selected for rodent pharmacokinetic and in vivo antimalarial efficacy studies in the mouse Plasmodium berghei and Plasmodium falciparum Pf3D70087/N9 severe combined immunodeficiency (SCID) mouse models. The results indicate that the 4-benzylamino derivatives have excellent profiles with a representative of this series, N205, an excellent starting point for further lead optimization studies.

subjects

  • Biology and Biomedicine
  • Medicine

keywords

  • plasmodium-falciparum malaria; antimalarial-activity; western cambodia; artemisinin; oz439; resistance; oz277