Case study of small molecules as antimalarials: 2-amino-1-phenylethanol (APE) derivatives Articles uri icon

authors

  • CHAPARRO, MARIA J.
  • VIDAL, JAUME
  • ANGULO BARTUREN, ÍÑIGO
  • BUENO, JOSE M.
  • BURROWS, JEREMY
  • CAMMACK, NICHOLAS
  • CASTAÑEDA, PABLO
  • COLMENAREJO, GONZALO
  • COTERON, JOSE M.
  • DE LAS HERAS, LAURA
  • FERNANDEZ, ESTHER
  • FERRER BAZAGA, SANTIAGO
  • GABARRO, RAQUEL
  • GAMO, FRANCISCO J.
  • GARCIA, MERCEDES
  • JIMENEZ-DIAZ, MARIA B.
  • LAFUENTE, MARIA J.
  • LEON, MARIA L.
  • MARTINEZ, MARIA S.
  • MINICK, DOUGLAS
  • PRATS, SARA
  • PUENTE, MARGARITA
  • RUEDA, LOURDES
  • SALDOVAL, ELENA
  • SANTOS VILLAREJO, ÁNGEL
  • WITTY, MICAEL
  • CALDERON, FELIX

publication date

  • June 2014

start page

  • 657

end page

  • 661

issue

  • 6

volume

  • 5

International Standard Serial Number (ISSN)

  • 1948-5875

abstract

  • Antiparasitic oral drugs have been associated to lipophilic molecules due to their intrinsic permeability. However, these kind of molecules are associated to numerous adverse effects, which have been extensively studied. Within the Tres Cantos Antimalarial Set (TCAMS) we have identified two small, soluble and simple hits that even presenting antiplasmodial activities in the range of 0.4-0.5 ÎM are able to show in vivo activity.

subjects

  • Biology and Biomedicine
  • Medicine

keywords

  • aminoalcoholes; malaria; mefloquine; tcams; tres cantos antimalarial set