Cu5Cr35Fe35V20-X5, with X = Ti, Ta or W, alloys were produced by arc melting to assess their feasibility to be used as structural materials and as interlayer in cooling systems. The microstructure and mechanical properties of the materials were analyzed in as-cast and aged states. In the as-cast state the structure of the three alloys is BCC, but formation of the intermetallic Fe7Ta3 is observed in Cu5Cr35Fe35V20Ta5. Thermal aging treatment at 700 °C caused significant changes in the microstructure of Cu5Cr35Fe35V20W5 and the formation of the sigma phase. Thermal treated Cu5Cr35Fe35V20Ta5 and Cu5Cr35Fe35V20W5 exhibit high mechanical strength and excellent compressive ductility but show work softening due to the appearance of dynamic recovery mechanisms. Type-A serration behavior is observed for Cu5Cr35Fe35V20W5. Both, the complexity of their microstructures and their differences are responsible for the different mechanical behavior of the three alloys.