This article presents the design of a uni-planar MIMO antenna system for sub-6 GHz 5G-enabled smartphones. The MIMO antenna designed comprises four loop-shaped radiators placed at each corner of the mobile phone board, which follows the principle of pattern diversity. The single-antenna element resonates at 3.5 GHz, its impedance bandwidth is noted to be 1.28 GHz (3–4.28 GHz) for S11 90%. The isolation of >10 dB between antenna elements is achieved for the MIMO configuration. Furthermore, the MIMO antenna designed provides enough radiation coverage to support different sides of the mobile phone board, which is an important feature for future 5G-enabled handsets. In addition, the impacts of human hands and heads on MIMO antenna performance are investigated, and acceptable performance in the data and conversation modes is observed.