Advanced g-mps-pmma bone cements: Influence of graphene silanisation on fatigue performance, thermal properties and biocompatibility Articles uri icon

authors

  • Paz, Eva
  • BALLESTEROS IGLESIAS, YOLANDA
  • ABENOJAR BUENDIA, JUANA
  • Dunne, Nicholas
  • DEL REAL ROMERO, JUAN CARLOS

publication date

  • January 2021

start page

  • 1

end page

  • 17

issue

  • 1

volume

  • 11

International Standard Serial Number (ISSN)

  • 2079-4991

abstract

  • The incorporation of well-dispersed graphene (G) powder to polymethyl methacrylate (PMMA) bone cement has been demonstrated as a promising solution to improving its mechanical performance. However, two crucial aspects limit the effectiveness of G as a reinforcing agent: (1) the poor dispersion and (2) the lack of strong interfacial bonds between G and the matrix of the bone cement. This work reports a successful functionalisation route to promote the homogenous dispersion of G via silanisation using 3-methacryloxypropyltrimethoxy silane (MPS). Furthermore, the effects of the silanisation on the mechanical, thermal and biocompatibility properties of bone cements are presented. In comparison with unsilanised G, the incorporation of silanised G (G_MPS1 and G_MPS2) increased the bending strength by 17%, bending modulus by 15% and deflection at failure by 17%. The most impressive results were obtained for the mechanical properties under fatigue loading, where the incorporation of G_MPS doubled the Fatigue Performance Index (I) value of unsilanised G-bone cement-meaning a 900% increase over the I value of the cement without G. Additionally, to ensure that the silanisation did not have a negative influence on other fundamental properties of bone cement, it was demonstrated that the thermal properties and biocompatibility were not negatively impacted—allowing its potential clinical progression.

keywords

  • biocompatibility; bone cement; fatigue; graphene; mechanical properties; silane; silanisation; thermal properties