Association of porcine swine leukocyte antigen (Sla) haplotypes with b-and t-cell immune response to foot-and-mouth disease virus (fmdv) peptides Articles uri icon


  • Leon, Patricia de
  • CaƱas Arranz, Rodrigo
  • Forner, Mar
  • Defaus, Sira
  • Bustos, Maria J.
  • Torres, Elisa
  • Andreu, David
  • Blanco, Esther
  • Sobrino, Francisco
  • Hammer, Sabine E.

publication date

  • September 2020

start page

  • 1

end page

  • 16


  • 3


  • 8

International Standard Serial Number (ISSN)

  • 2076-393X


  • Dendrimer peptides are promising vaccine candidates against the foot-and-mouth disease virus (FMDV). Several B-cell epitope (B2T) dendrimers, harboring a major FMDV antigenic B-cell site in VP1 protein, are covalently linked to heterotypic T-cell epitopes from 3A and/or 3D proteins, and elicited consistent levels of neutralizing antibodies and IFN-gamma-producing cells in pigs. To address the contribution of the highly polymorphic nature of the porcine MHC (SLA, swine leukocyte antigen) on the immunogenicity of B2T dendrimers, low-resolution (Lr) haplotyping was performed. We looked for possible correlations between particular Lr haplotypes with neutralizing antibody and T-cell responses induced by B2T peptides. In this study, 63 pigs immunized with B2T dendrimers and 10 non-immunized (control) animals are analyzed. The results reveal a robust significant correlation between SLA class-II Lr haplotypes and the T-cell response. Similar correlations of T-cell response with SLA class-I Lr haplotypes, and between B-cell antibody response and SLA class-I and SLA class-II Lr haplotypes, were only found when the sample was reduced to animals with Lr haplotypes represented more than once. These results support the contribution of SLA class-II restricted T-cells to the magnitude of the T-cell response and to the antibody response evoked by the B2T dendrimers, being of potential value for peptide vaccine design against FMDV.


  • adaptive immunity; dendrimer peptide; foot-and-mouth disease virus; protection; sla polymorphism; swine; swine leukocyte antigen; vaccine