Preparation, thermoresponsive behavior, and preliminary biological study of functionalized poly(N-isopropylacrylamide-co-dopamine methacrylamide) copolymers with an organotin(IV) compound Articles uri icon

authors

  • GARCIA PEÑAS, ALBERTO
  • Yu, Wang
  • Mena Palomo, Irene
  • López Collazo, Eduardo
  • Díaz García, Diana
  • GÓMEZ-RUIZ, SANTIAGO
  • STADLER, FLORIAN J.

publication date

  • February 2021

start page

  • 1

end page

  • 10

issue

  • 107046

volume

  • 94

International Standard Serial Number (ISSN)

  • 0142-9418

Electronic International Standard Serial Number (EISSN)

  • 1873-2348

abstract

  • Recent advances focused on smart polymers have demonstrated the numerous advantages regarding other structures because they can adapt the behavior depending on physicochemical properties. In this way, functionalized thermoresponsive polymers with organometallic complexes were profoundly analyzed. Consequently, novel catalytic systems or biomedical devices could be developed. This publication focuses on the facile preparation of poly(N-isopropylacrylamide-co-dopamine methacrylamide) copolymers functionalized with triphenyltin chloride by protonolysis through the –OH of catechol groups. The presence of hydrophobic organotin(IV) derivatives could modify the solubility, thermoresponsive behavior, and other properties regarding pure copolymers. Also, sensitive analysis of the microstructure could help to understand the changes associated with the lower critical solution temperature by rheology, UV–vis spectroscopy, and calorimetry. In addition, a preliminary biological study against MDA-MB-231 cancer cells and peripheral blood mononuclear cells showed that the functionalized copolymers could be a potential platform to be explored in the future in the fight against cancer.

keywords

  • thermoresponsive polymers; organotin(iv) derivatives; functionalized structures; biocompatibility