Large-Scale Production of LGR5-Positive Bipotential Human Liver Stem Cells Articles uri icon

authors

  • Schneeberger, Kerstin
  • Sanchez-Romero, Natalia
  • Ye, Shicheng
  • van Steenbeek, Frank G.
  • Oosterhoff, Loes A.
  • Pla Palacin, Iris
  • CHEN, CHEN
  • van Wolferen, Monique E.
  • van Tienderen, Gilles
  • Lieshout, Ruby
  • Colemonts Vroninks, Haaike
  • Schene, Imre
  • Hoekstra, Ruurdtje
  • Verstegen, Monique M.A.
  • van der Laan, Luc J.W.
  • Penning, Louis C.
  • Fuchs, Sabine A.
  • Clevers, Hans
  • De Kock, Joery
  • ALMEIDA DE MATOS BAPTISTA, PEDRO MIGUEL
  • Spee, Bart

publication date

  • July 2020

start page

  • 257

end page

  • 270

issue

  • 1

volume

  • 72

International Standard Serial Number (ISSN)

  • 0270-9139

Electronic International Standard Serial Number (EISSN)

  • 1527-3350

abstract

  • BACKGROUND AND AIMS: The gap between patients on transplant waiting lists and available donor organs is steadily increasing. Human organoids derived from leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5)&-positive adult stem cells represent an exciting new cell source for liver regeneration; however, culturing large numbers of organoids with current protocols is tedious and the level of hepatic dif-ferentiation is limited. [...]