Large-scale production of LGR5-positive bipotential human liver stem cells Articles uri icon

authors

  • SCHNEEBERGER, KERSTIN
  • SANCHEZ ROMERO, NATALIA
  • YE, SHICHENG
  • STEENBEEK, FRANK G. VAN
  • OOSTERHOFF, LOES A.
  • PLA PALACIN, IRIS
  • CHEN, CHEN
  • VAN WOLFEREN, MONIQUE E.
  • VAN TIENDEREN, GILLES
  • LIESHOUT, RUBY
  • COLEMONTS VRONINKS, HAAIKE
  • SCHENE, IMRE
  • HOEKSTRA, RUURDTJE
  • VERSTEGEN, MONIQUE M.A.
  • VAN DER LAAN, LUC J. W.
  • PENNING, LOUIS C.
  • FUCHS, SABINE A.
  • CLEVERS, HANS
  • DE KOCK, JOERY
  • ALMEIDA DE MATOS BAPTISTA, PEDRO MIGUEL
  • SPEE, BART

publication date

  • July 2020

start page

  • 257

end page

  • 270

issue

  • 1

volume

  • 72

International Standard Serial Number (ISSN)

  • 0270-9139

Electronic International Standard Serial Number (EISSN)

  • 1527-3350

abstract

  • BACKGROUND AND AIMS: The gap between patients on transplant waiting lists and available donor organs is steadily increasing. Human organoids derived from leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5)-positive adult stem cells represent an exciting new cell source for liver regeneration; however, culturing large numbers of organoids with current protocols is tedious and the level of hepatic dif-ferentiation is limited. [...]

subjects

  • Biology and Biomedicine
  • Medicine