Toward a Morphodynamic Model of the Cell: Signal processing for cell modeling Articles uri icon

publication date

  • January 2015

start page

  • 20

end page

  • 29

issue

  • 1

volume

  • 32

International Standard Serial Number (ISSN)

  • 1053-5888

Electronic International Standard Serial Number (EISSN)

  • 1558-0792

abstract

  • Abstract: From a systems biology perspective, the cell is the principal element of information integration. Therefore, understanding the cell in its spatiotemporal context is the key to unraveling many of the still unknown mechanisms of life and disease. This article reviews image processing aspects relevant to the quantification of cell morphology and dynamics. We cover both acquisition (hardware) and analysis (software) related issues, in a multiscale fashion, from the detection of cellular components to the description of the entire cell in relation to its extracellular environment. We then describe ongoing efforts to integrate all this vast and diverse information along with data about the biomechanics of the cell to create a credible model of cell morphology and behavior.

keywords

  • biomedical imaging; cells biology; image resolution; diseases; spatiotemporal phenomena; biomechanics; cell morphology; spatiotemporal phenomenal; cytology; image processing; medical imaging; morphology; signal processing; cellular components; extracellular environments; information integration; morphodynamic modeling; systems biology; cells