The role of extracellular matrix on liver stem cell fate: A dynamic relationship in health and disease Articles uri icon

authors

  • SANCHEZ ROMERO, NATALIA
  • SAINZ ARNAL, PILAR
  • PLA PALACIN, IRIS
  • ROYO DACHARY, PABLO
  • ALMEDA, HELEN
  • PASTOR, CRISTINA
  • SOTO RUBIO, DANIELA
  • CHICO RODRIGUEZ, MILAGROS
  • OLMEDO ARBIZU, EMMA
  • BENGOCHEA MARTINEZ, LOURDES
  • SERRANO AULLO, TRINIDAD
  • ALMEIDA DE MATOS BAPTISTA, PEDRO MIGUEL

publication date

  • April 2019

start page

  • 49

end page

  • 56

volume

  • 106

International Standard Serial Number (ISSN)

  • 0301-4681

Electronic International Standard Serial Number (EISSN)

  • 1432-0436

abstract

  • The liver stem cell niche is a specialized and dynamic microenvironment with biomechanical and biochemical characteristics that regulate stem cell behavior. This is feasible due to the coordination of a complex network of secreted factors, small molecules, neural, blood inputs and extracellular matrix (ECM) components involved in the regulation of stem cell fate (self-renewal, survival, and differentiation into more mature phenotypes like hepatocytes and cholangiocytes). In this review, we describe and summarize all the major components that play essential roles in the liver stem cell niche, in particular, growth factor signaling and the biomechanical properties of the ECM.

keywords

  • liver development; ecm; stem cell; progenitor cell; stem cell niche; growth factors; mechanobiology; multipotent stem/progenitor cells; long-term culture; growth-factor; biliary tree; adhesion molecules; progenitor cells; adult liver; niche; regeneration; mechanisms