Naturally-Derived Biomaterials for Tissue Engineering Applications Articles uri icon

authors

  • BROVOLD, MATTHEW
  • ALMEIDA, JOANA I.
  • PLA PALACIN, IRIS
  • SAINZ ARNAL, PILAR
  • SANCHEZ ROMERO, NATALIA
  • RIVAS, JESUS J.
  • ALMEIDA, HELEN
  • ROYO DACHARY, PABLO
  • SERRANO AULLO, TRINIDAD
  • SOKER, SHAY
  • ALMEIDA DE MATOS BAPTISTA, PEDRO MIGUEL

publication date

  • January 2018

start page

  • 421

end page

  • 449

volume

  • 1077

International Standard Serial Number (ISSN)

  • 0065-2598

abstract

  • Naturally-derived biomaterials have been used for decades in multiple regenerative medicine applications. From the simplest cell microcarriers made of collagen or alginate, to highly complex decellularized whole-organ scaffolds, these biomaterials represent a class of substances that is usually first in choice at the time of electing a functional and useful biomaterial. Hence, in this chapter we describe the several naturally-derived biomaterials used in tissue engineering applications and their classification, based on composition. We will also describe some of the present uses of the generated tissues like drug discovery, developmental biology, bioprinting and transplantation.

keywords

  • naturally-derived materials; tissue decellularization; tissue engineering; protein-based biomaterials; polysaccharide-based biomaterials; glycosaminoglycans; extracellular matrix-derived biomaterials; solid organ bioengineering; regulatory landscape for naturally-derived biomaterials; donor liver-transplantation; small-intestinal submucosa; qt interval prolongation; embryonic stem-cells; for-size syndrome; in-vitro; extracellular-matrix; regenerative medicine; primary hepatocytes; heart-valves