Deregulated FADD expression and phosphorylation in T-cell lymphoblastic lymphoma Articles uri icon

authors

  • MARÍN RUBIO, JOSÉ L.
  • ARRIBA PEREZ, MARIA DEL CARMEN DE
  • COBOS FERNÁNDEZ, MARÍA A.
  • GONZÁLEZ SÁNCHEZ, LAURA
  • ORS, INMACULADA
  • SASTRE, ISABEL
  • FERNÁNDEZ PIQUERAS, JOSÉ
  • VILLA MORALES, MARÍA

publication date

  • August 2016

start page

  • 61485

end page

  • 61499

issue

  • 38

volume

  • 7

Electronic International Standard Serial Number (EISSN)

  • 1949-2553

abstract

  • In the present work, we show that T-cell lymphoblastic lymphoma cells exhibit a reduction of FADD availability in the cytoplasm, which may contribute to impaired apoptosis. In addition, we observe a reduction of FADD phosphorylation that inversely correlates with the proliferation capacity and tumor aggressiveness. The resultant balance between FADD-dependent apoptotic and non-apoptotic abilities may define the outcome of the tumor. Thus, we propose that FADD expression and phosphorylation can be reliable biomarkers with prognostic value for T-LBL stratification.

subjects

  • Biology and Biomedicine
  • Electronics
  • Medicine

keywords

  • t-cell lymphoblastic lymphoma; fas-associated death domain protein (fadd); expression and phosphorylation; tumor aggressiveness; prognostic marker