New experimental models of skin homeostasis and diseases Articles uri icon

publication date

  • January 2015

start page

  • 17

end page

  • 28

issue

  • 1

volume

  • 106

International Standard Serial Number (ISSN)

  • 1578-2190

abstract

  • Homeostasis, whose regulation at the molecular level is still poorly understood, is intimately related to the functions of epidermal stem cells. Five research groups have been brought together to work on new in vitro and in vivo skin models through the SkinModel-CM program, under the auspices of the Spanish Autonomous Community of Madrid. This project aims to analyze the functions of DNA methyltransferase 1, endoglin, and podoplanin in epidermal stem cell activity, homeostasis, and skin cancer. These new models include 3-dimensional organotypic cultures, immunodeficient skin-humanized mice, and genetically modified mice. Another aim of the program is to use skin-humanized mice to model dermatoses such as Gorlin syndrome and xeroderma pigmentosum in order to optimize new protocols for photodynamic therapy.

keywords

  • skinmodel-cm software; epidermal stem cells; dna methyltransferase 1; endoglin; podoplanin; genetically modified mice; three-dimensional skin equivalents skin-humanized mice. photodynamic therapy