Tissue-engineered oral mucosa for mucosal reconstruction in a pediatric patient with hemifacial microsomia and ankyloglossia Articles uri icon

publication date

  • March 2014

start page

  • 146

end page

  • 251


  • 2


  • 51

International Standard Serial Number (ISSN)

  • 1055-6656

Electronic International Standard Serial Number (EISSN)

  • 1545-1569


  • Many types of soft tissue grafts have been used for the reconstruction of oral mucosal defects. The best results are achieved with mucosal grafts; however, when large areas must be grafted, sufficient donor tissue is not available. Tissue engineering represents an alternative method to obtain sufficient autologous tissue for reconstructing oral wounds. Herein we present a pediatric patient with hemifacial microsomia and congenital ankyloglossia requiring multiple surgical interventions, and in which an autologous full-thickness tissue-engineered oral mucosa was used for successful oral reconstruction. Our study demonstrates that even under challenging conditions, robust tissue-engineered products, such as the fibrin-based oral mucosa described here, can achieve successful tissue regeneration. © Copyright 2014 American Cleft Palate-Craniofacial Association.


  • collagenase; fibrinogen; fresh frozen plasma; tissue scaffold; tranexamic acid; acellular dermal matrix; ankyloglossia; article; case report; cell culture; cheek mucosa; child; culture medium; enzyme degradation; epithelization; facial nerve paralysis; fibroblast culture; follow up; graft failure; hemifacial microsomia; human; human cell; hypodontia; keratinocyte; mandible; mandible hypoplasia; mandibular nerve; maxillofacial surgery; mouth mucosa; oral surgery; palatopharyngeal incompetence; physical examination; plastic surgery; preschool child; priority journal; recurrent disease; scar formation; skin graft; surgical wound; tissue culture; tissue engineering; wound healing