Tissue-engineered oral mucosa for mucosal reconstruction in a pediatric patient with hemifacial microsomia and ankyloglossia

Many types of soft tissue grafts have been used for the reconstruction of oral mucosal defects. The best results are achieved with mucosal grafts; however, when large areas must be grafted, sufficient donor tissue is not available. Tissue engineering represents an alternative method to obtain sufficient autologous tissue for reconstructing oral wounds. Herein we present a pediatric patient with hemifacial microsomia and congenital ankyloglossia requiring multiple surgical interventions, and in which an autologous full-thickness tissue-engineered oral mucosa was used for successful oral reconstruction. Our study demonstrates that even under challenging conditions, robust tissue-engineered products, such as the fibrin-based oral mucosa described here, can achieve successful tissue regeneration. © Copyright 2014 American Cleft Palate-Craniofacial Association.

collagenase; fibrinogen; fresh frozen plasma; tissue scaffold; tranexamic acid; acellular dermal matrix; ankyloglossia; article; case report; cell culture; cheek mucosa; child; culture medium; enzyme degradation; epithelization; facial nerve paralysis; fibroblast culture; follow up; graft failure; hemifacial microsomia; human; human cell; hypodontia; keratinocyte; mandible; mandible hypoplasia; mandibular nerve; maxillofacial surgery; mouth mucosa; oral surgery; palatopharyngeal incompetence; physical examination; plastic surgery; preschool child; priority journal; recurrent disease; scar formation; skin graft; surgical wound; tissue culture; tissue engineering; wound healing

Tissue-engineered oral mucosa for mucosal reconstruction in a pediatric patient with hemifacial microsomia and ankyloglossia Articles