This paper describes, analyses and evaluates the methodologies that have been used within the C@R Integrated Project for launching and developing seven rural living labs innovation environments. After introducing the living lab experimentation environments, we describe the methodological framework developed in C@R. It is distinguished between strategic methodologies to establish and shape the living labs, and operational methodologies to run living lab innovation projects as experimentation and evaluation cycles. We discuss and assess how the living lab methodological framework has been implemented in the living labs and which lessons can be learned. Finally on the basis of a socio-technical change perspective we provide a wider outlook into the role of living labs as instruments and strategies for innovation and discuss implications for policy.