Nucleotide Variation in Central Nervous System Genes Among Male Suicide Attempters Articles uri icon

authors

  • BACA GARCIA, ENRIQUE
  • VAQUERO-LORENZO, CONCEPCION
  • PEREZ RODRIGUEZ, MM
  • GRATACOS, MONICA
  • BAYES, M.
  • SANTIAGO MOZOS, RICARDO
  • LEIVA MURILLO, JOSE MIGUEL
  • PRADO CUMPLIDO, MARIO DE
  • ARTES RODRIGUEZ, ANTONIO
  • CEVERINO, ANTONIO
  • DIAZ SASTRE, CARMEN
  • FERNANDEZ NAVARRO, P.
  • FERNANDEZ PIQUERAS, J.
  • DIAZ HERNANDEZ, M.
  • LEON, J DE
  • BACA BALDOMERO, E.
  • SAIZ RUIZ, J.
  • MANN, J. JOHN
  • PARSEY, R. V.
  • CARRACEDO, A.
  • ESTIVILL, X.
  • OQUENDO, MA

publication date

  • January 2010

start page

  • 208

end page

  • 213

issue

  • 1

volume

  • 153B

international standard serial number (ISSN)

  • 1552-4841

abstract

  • Despite marked morbidity and mortality associated with suicidal behavior, accurate identification of individuals at risk remains elusive. The goal of this study is to identify a model based on single nucleotide polymorphisms (SNPs) that discriminates between suicide attempters and non-attempters using data mining strategies. We examined functional SNPs (n = 840) of 312 brain function and development genes using data mining techniques. Two hundred seventy-seven male psychiatric patients aged 18 years or older were recruited at a University hospital psychiatric emergency room or psychiatric short stay unit. The main outcome measure was history of suicide attempts. Three SNPs of three genes (rs10944288, HTR1E; hCV8953491, GABRP; and rs707216, ACTN2) correctly classified 67% of male suicide attempters and non-attempters (0.50 sensitivity, 0.82 specificity, positive likelihood ratio = 2.80, negative likelihood ratio = 1.64). The OR for the combined three SNPs was 4.60 (95% CI: 1.31&-16.10). The model's accuracy suggests that in the future similar methodologies may generate simple genetic tests with diagnostic utility in identification of suicide attempters. This strategy may uncover new pathophysiological pathways regarding the neurobiology of suicidal acts.