In the present study, we used tensile shear tests, Shore hardness tests, differential scanning calorimetry (DSC), and thermogravimetry (TGA) to characterize a reactive polyurethane-based hot melt adhesive. We also measured contact angles at various temperatures to evaluate the wettability of the adhesive and to determine the optimum temperature range for applications. The adhesive was tested following curing for various times, and the bonding of the adhesive with several materials was investigated to determine whether it has the potential for greater versatility of application. Therefore, we explored new uses of the adhesive, such as in the matrix of a composite with fiberglass. Reactive hot melt adhesives are useful because they provide a certain degree of flexibility to joints, and have high processing speeds, high initial rigidity, and high working temperatures.